Solubility of theophylline in water
WebThe solubility of theophylline – oxalic acid co-crystal and theophylline – glutaric acid co-crystal was determined in 4:1 chlroform – methanol and in pure chloroform respectively. At equilibrium with the solid theophylline – oxalic acid co-crystal, the theophylline concentration is only 60 % of the corresponding value for the WebCaffeine, theobromine, and theophylline are all more fat soluble than they are water soluble. 5 mo. ago. Thank you! Does the extra methyl group on caffeine (as opposed to theophylline, theobromine and paraxanthine) not make a difference? Patrick26. The presence or absence of that methyl group does affect the solubilities, but they are still ...
Solubility of theophylline in water
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WebAug 24, 2024 · Solubility is a very important property of drugs involved in purification processes and the different pharmaceutical dosage form design stages. Otherwise, … WebC s is the solubility of theophylline and k is the pH of the theophylline solution. The results are shown in Table 4.From the table,it is seen that, the solubility of theophylline increases …
WebThe solubility of theophylline in mixed solvents consisting of dioxane and water was determined at 25 +/- 0.1 degrees. The solubilities across this range of polar solvents were back-calculated using a technique involving an interaction energy term, W. WebTheophylline is a cyclic phosphodiesterase inhibitor. It antagonizes Adenosine A Receptors and weakly inhibits alkaline phosphodiesterases and 5′-nucleotidase. ... Soluble in water (8.3 g/l) at 20° C, 0.1 M NaOH, 0.1 M HCl, ethanol (moderately), DMSO, alkali hydroxides, ammonia, dilute hyrochloric acid, nitric acid, ...
WebDimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility K Avgoustakis 2007, International Journal of Pharmaceutics Theophylline, also known as 1,3-dimethylxanthine, is a phosphodiesterase inhibiting drug used in therapy for respiratory diseases such as chronic obstructive pulmonary disease (COPD) and asthma under a variety of brand names. As a member of the xanthine family, it bears structural and pharmacological similarity to theobromine and caffeine, and is readily found in …
WebJan 1, 2015 · Theophylline is dimethylxanthine which is closely related chemically to caffeine (Fig. 1 ). Like caffeine, theophylline is sparingly soluble in water (7 g/l). The logP value of theophylline is –0.02 giving the unionized form sufficient lipid solubility to diffuse passively through cell membranes. Theophylline is a weak acid (pKa 8.8).
WebFeb 27, 2024 · Theophylline is a methylxanthine alkaloid that is a competitive inhibitor of phosphodiesterase (PDE; Ki = 100 μM). It is also a non-selective antagonist of adenosine A receptors (Ki = 14 μM for A1 and A2). Theophylline induces relaxation of feline bronchiole smooth muscle precontracted with acetylcholine (EC40 = 117 μM; EC80 = 208 μM). grand rapids chamber of commerce loginWebOct 9, 2013 · In this paper, the influence of polymorphs on the transformation water activity that corresponds to the transformation between hydrate and anhydrate of theophylline was investigated. Theophylline is known to exist either as anhydrates or a monohydrate. The transformation water activities of theophylline form II and IV were determined … chinese new year animal storychinese new year animals with datesWebMar 1, 1983 · The solubilities of theophylline and theophylline hydrate as a function of temperature are determined in the temperature range 288–365K. The solubility as a … chinese new year animals tigerWebAbstract - The solubility of caffeine in water, ethyl acetate, ethanol, carbon tetrachloride, methanol, chloroform, ... It belongs to the group of chemicals known as methylxanthines, which also includes the closely related chemicals theophylline and theobromine. In its pure form, caffeine occurs as odorless, white, fleecy masses, ... chinese new year animated gifWebAminophylline is soluble in water and insoluble in alcohol. Theophylline occurs as bitter-tasting, odorless, white, crystalline powder with a melting point between 270-274°C. It is sparingly soluble in alcohol and only slightly soluble in water at a pH of 7, but solubility increases with increasing pH. chinese new year animal story for kidsWebIn the present study, hydrotropic solubilization technique has been used to solubilize the poorly water soluble anti-diuretic drugs such as theophylline for its spectrophotometric analysis. Sodium salicylate and resorcinol solutions of strength 7.5 M and 5.5 M respectively, have been used as a hydrotropic agent. Compared to the solubility in distilled … chinese new year anime girl