Sec62 sec61 interaction

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August undefined, 2024

WebSEC62 1 Systematic Name YPL094C SGD ID SGD:S000006015 Aliases LPG14 Feature Type ... Description Essential subunit of Sec63 complex; with Sec61 complex, ... Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. An interaction annotation is composed of the interaction ... Web2 Oct 2013 · Figure 1. Various protein-protein interactions are involved in gating of the Sec61-complex in the human ER membrane. The interactions of BiP and Ca 2+-CaM with Sec61α and of Sec62 with Sec61α and Sec63 as well as their sensitivities to mutations and small molecules, respectively, were previously described. 3, 14, 16 The BiP-Sec63 …

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Web26 Sep 2024 · identify Sec62 as a critical molecular component in maintenance and recovery of endoplasmic reticulum homeostasis; Interaction of ribosomes and Sec62 with the core … Web28 Apr 2024 · Taken together, it was shown that Sec61 and Sec62 bear important functions beyond the protein translocation process, indicating that Sec proteins can influence intracellular signaling in various manners. How these additional functions are controlled in detail and how they are linked to other cellular signaling pathways remain elusive. speedy york

Sec61γ is a vital protein in the endoplasmic reticulum membrane ...

Web4 Dec 2015 · Sec62 interacts with Sec61 in a ribosome-sensitive manner. We first compared the interaction profile of Sec61 with translocon-associated proteins in intact canine pancreatic rough microsomes (RMs), where >80% of translocons are engaged with ribosomes45, and microsomes stripped of ribosomes by puromycin-high salt treatment … Web3 Oct 2024 · SEC61, SEC62 and SEC63 gene overexpression or mutation associated with human tumor diseases. Over the past 15 years, increasing evidence suggests a relevant … WebSec62 in mammals can form a complex with Sec61, assisting protein translocation in the endoplasmic reticulum membrane. It also interacts with Sec63, an endoplasmic reticulum protein containing... speedy you a fool for this one

SEC62 Gene - GeneCards SEC62 Protein SEC62 Antibody

Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

WebDepletion of Sec62 from either type of SEC62 overexpressing tumor cells by treatment with SEC62 -targeting siRNAs leads to reduced stress tolerance and reduced migratory as well … Web28 Apr 2024 · An additional function for Sec61 apart from protein translocation was suggested by several studies, indicating that Sec61 could also serve as a Ca 2+ channel … speedy yearly current affairs pdf 2022Web11 Jul 2006 · SEC62 and SEC63 are required for interactions between SEC61 and translocating polypeptides. SEC62 may affect SEC1-polypeptide interactions by … speedy yt

"Web4 Jan 2024 · We show that Sec62 and Sec63 cooperate to open both the lateral and the vertical gates of the Sec61 channel. The structures and molecular dynamics (MD) simulations also suggest that Sec62... " - Sec62 sec61 interaction

Sec62 sec61 interaction

The ER luminal C‐terminus of AtSec62 is critical for male fertility …

Web4 Dec 2015 · Here we have explored the interaction of both Sec62 and SR with the mammalian translocon and find that interaction of ribosomes and Sec62 with the core … Web20 Jul 2016 · In yeast, Sec63 associates with the trimeric Sec61 complex and Sec62 ( 602173) in an ER membrane complex involved in posttranslational transport of newly synthesized proteins. By searching an EST database for sequences similar to yeast Sec63, Skowronek et al. (1999) identified human SEC63.

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Web14 Dec 2024 · 13 gating steps of Sec61 and the mechanism by which Sec62 and Sec63 induce these gating events. We show 14 that Sec62 forms a V-shaped structure in front of the lateral gate to fully open both gates of Sec61. 15 Without Sec62, the lateral gate opening narrows, and the vertical pore becomes closed by the plug, 16 rendering the channel … Web9 Nov 2024 · It suggests that Sec62 interacts with Sec61 rather weakly whereas it forms a relatively stable tetramer complex with Sec63, 31.5, and 23 kDa proteins. The 31.5 and 23 …

WebBioGRID Interaction 463211 Between SEC62 And SEC61. Toggle navigation. Bio GRID 4.4 WebSEC61 SSS1. Co-purification. Co-purification. An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by …

WebThe disul- fide linkage between Deg1-Sec62 and the Sec61 channel may strengthen the interaction of the Sec62 N-domain with a signal sequence-binding site within the channel. … WebA cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing …

Web16 Nov 2024 · We determined a structure of the Sec complex (Sec61-Sec63-Sec71-Sec72) from Saccharomyces cerevisiae by cryo-electron microscopy (cryo-EM). The structure shows that Sec63 tightly associates with Sec61 through interactions in cytosolic, transmembrane, and ER-luminal domains, prying open Sec61's lateral gate and …

Web9 Nov 2024 · Most secreted and membrane proteins are targeted to and translocated across the endoplasmic reticulum (ER) membrane through the Sec61 protein-conducting channel. Evolutionarily conserved Sec62 and Sec63 associate with the Sec61 channel, forming the Sec complex and mediating translocation of a subset of proteins. For the last three … speedy young justiceWebThus, the human Sec62/Sec63 complex may support Sec61-channel opening for precursor polypeptides with slowly gating SPs by direct interaction with the cytosolic amino … speedy zapata actorWeb28 Feb 1991 · These results confirm previous predictions, based upon genetic interactions between the SEC genes, that Sec61, Sec62 and Sec63 act together to facilitate protein translocation into the ER. speedy143Web6 Oct 2024 · The heterotrimeric Sec61 protein complex forms the functional core of the so-called translocon that forms an aqueous channel in the endoplasmic reticulum (ER). The primary role of the Sec61 complex is to allow protein import in the ER during translation. speedy143virtual.wixsite.comWeb5 Aug 2024 · The signal sequence is flanked by two Sec62 transmembrane helices, the cytoplasmic N-terminal domain of Sec62 is more rigidly positioned, and the plug domain is relocated. We crystallized the Sec62 domain and mapped its interaction with the C-terminus of Sec63. Together, we obtained a near-complete and integrated model of the active Sec … speedy yvelinesWeb21 Mar 2024 · The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation … speedy-feet.com speedy124