Phenome-wide association study

Author: rwqc

August undefined, 2024

WebOct 16, 2024 · Phenome-wide association studies (PheWAS) have been proposed as a possible aid in drug development through elucidating mechanisms of action, identifying … WebApr 12, 2024 · Previous genome-wide association studies (GWASs) investigated single nucleotide polymorphisms (SNPs) that influence the antibody responses against VZV infections. ... Our phenome-wide MR study found anti-VZV IgG to be a causal risk factor of 22 traits, which helped gain new insights into the causal roles of VZV-specific immunity in …

Frontiers Using phenome-wide association studies and the SF-12 ...

WebJul 13, 2024 · Results. We identified 14 independent loci associated (P < 5 × 10 −8) with estradiol levels in males, of which 1 (CYP3A7) was genome-wide and 7 nominally (P < 0.05) significant in females.In addition, 1 female-specific locus was identified. Most loci contain functionally relevant genes that have not been discussed in relation to estradiol levels in … WebPhenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims … spine align knee pillow

A phenome-wide association study of genetically mimicked statins

WebPhenome-wide association studies (PheWAS) analyze many phenotypes compared to a single genetic variant (or other attribute). This method was originally described using … WebApr 12, 2024 · Previous genome-wide association studies (GWASs) investigated single nucleotide polymorphisms (SNPs) that influence the antibody responses against VZV … WebJun 30, 2024 · We performed a sex-specific phenome-wide association study assessing the association of genetic variants in HMGCR, mimicking statins, with 1701 phenotypes. We used Mendelian randomization (MR) to assess if any non-lipid effects found were evident for genetically mimicked PCSK9 inhibitors and ezetimibe or for LDL-c. Results spine align golf shaft

Phenome-Wide Association Study of Actigraphy in the UK Biobank

A Phenome-wide Association and Mendelian Randomization Study …

WebApr 28, 2024 · Phenome-wide association studies. The primary PheWAS analysis used SNPs identified from the HGI GWAS of critical and hospitalized COVID, and tested association of these SNPs with phenotypes extracted from the EHR using data prior to the COVID-19 pandemic. WebPhenome-wide association study (PheWAS) has been increasingly used to identify novel genetic associations across a wide spectrum of phenotypes. This systematic review aims to summarise the PheWAS methodology, discuss the advantages and challenges of PheWAS, and provide potential implications for future PheWAS studies. Medical Literature Analysis … spine align south africaWebThe genome-wide association study (GWAS) approach has well-developed methods and relatively straight-forward methodologies; however, the bigger picture of the impact of genetic architecture on phenotypic outcome still remains to be elucidated even with an ever-growing number of GWAS performed. spine align pillow dr loth

"WebMar 5, 2024 · Interpretation This study describes the extensive link between genetically determined COVID-19 and a broad range of diseases, especially those of the circulatory … " - Phenome-wide association study

Phenome-wide association study

Phenome-Wide Association Studies Genetics and …

WebDec 11, 2024 · Using data from approximately 100,000 participants in the UK Biobank, actigraphy-derived measures of physical activity, sleep, and diurnal rhythms were associated in exploration and validation cohorts with a full phenome-wide set of … WebApr 11, 2024 · We performed a phenome-wide association study of the index variants with 58 diseases, serum biomarkers, and physiological measurements, among 257 231 unrelated White British UK Biobank participants aged 55 years or older. Disease cases were identified using hospital diagnosis codes, procedure codes, and causes of death.

Did you know?

WebFeb 23, 2024 · The phenome-wide association study Open in figure viewer PowerPoint Once a curated medical phenome is in place, investigators can use a wide variety of input … WebIn this study, we conducted a phenome-wide association study (PheWAS) by genetic ancestry groups within a large academic health system using the polygenic risk score (PRS) for Alzheimer’s disease (AD). PRS was calculated using LDpred2 with genome-wide association study summary statistics. Phenotypes were extracted from electronic health ...

WebToward a Full Understanding of Causal and Modifiable Risk Factors for Alzheimer's Disease by Integrative Phenome-wide Association Studies Biol Psychiatry. 2024 May 1;93(9):756-758. doi: 10.1016/j.biopsych.2024.01.011. Authors Deng-Feng Zhang 1 , … WebAug 17, 2024 · The factors included in the PheWAS consisted of 10 broad categories (containing 4171 variables), which were 1) sociodemographic, 2) physical measures, 3) lifestyle and environment, 4) health conditions, 5) mental health, 6) medications and operations, 7) cognitive function, 8) sex-specific factors, 9) employment, and 10) early-life …

WebJun 30, 2024 · To fill this gap, we conducted a phenome-wide association study (PheWAS), a summary statistics-based genotype-to-phenotype approach [20, 21], to assess systematically the sex-specific associations of genetically mimicking statins with a wide range of conditions and related phenotypes, using the largest available genome-wide … WebAug 24, 2024 · We performed a phenome-wide association study (PheWAS) to explore the correlations between imaging phenotypes and 11 categories of non-imaging phenotypes …

WebOct 6, 2024 · Phenome-wide association studies. p-values ranging from p = 8.1 × 10 –32 to p = 3.91 × 10 –18. These values are reported in Supplementary Table 1, with the strongest associations (p < 1 × 10 –20) shown in Table 4. TABLE 4. Most significant associations of the dose-response phenome-wide association study. Phenotype Description:

WebMar 15, 2024 · Results of the phenome-wide association study for clinical outcomes in the UK Biobank and validation in the Penn Medicine BioBank and BioMe Biobank, and for … spine alignment seat cushionWebA phenome-wide study indicated that lower AFS was associated with a higher risk of coronary artery disease ... Küpers LK, et al. Identifying potential causal effects of age at menarche: a Mendelian randomization phenome-wide association study. BMC Med. 2024; 18 (1):71. doi: 10.1186/s12916-020-01515-y. [PMC free article] [Google Scholar] 14. ... spine aligned arrowsWebAug 24, 2024 · We then conducted a large, population-based phenome-wide association study to relate the cardiac and aortic phenotypes to non-imaging phenotypes. We discovered a wide range of highly... spine alignment machineWebBeginning in the early 2000s, the accumulation of biospecimens linked to electronic health records (EHRs) made possible genome-phenome studies (i.e., comparative analyses of … spine align wedge seat cushionWebPheWAS - Phenome Wide Association Studies PheWAS of GWAS Catalog of SNPs Phenotype Plot Genotype Chart PubMed Gene Info dbSNP Clear Filters Download this Full Catalog Chr 1 Snp 1 Phecode 1 Phenotype 1 Cases 1 P-Value 1 OR 1 Genes 1 19 50087459 rs2075650 290.11 Alzheimer's disease 737 5.24e-28 2.41 TOMM40 19 50087459 … spine alternative freeWebFeb 23, 2024 · The phenome-wide association study (PheWAS) is a method that enables a ‘reverse genetics’ experiment to be applied to human subjects (Abstract Figure). PheWAS takes advantage of increasingly large sets of human genetic variation coupled to dense phenotypic information often from electronic health records (EHRs) to analyse genotype ... spine always crackingWebJul 11, 2024 · A phenome-wide association study of PCSK9 loss-of-function (LoF) variants has the potential to predict adverse effects of PCSK9 inhibition and generate hypotheses about unknown beneficial effects. Comparing carriers of such LoF variants with noncarriers can simulate the effects of blocking the corresponding protein. spine alignment golf shaft