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P-stathmin

WebSep 8, 2015 · Stathmin and phospho-stathmin protein signature is associated with survival outcomes of breast cancer patients Oncotarget . 2015 Sep ... In conclusion, the STMN1 … WebJan 13, 2024 · The protein expression of p-stathmin (Ser16, Ser25, Ser38, and Ser63) in the hippocampus of the control group and SPS groups was detected by Western blotting. A single band was observed at 19 kDa. The results showed that the p-stathmin (Ser25) and p-stathmin (Ser38) proteins were expressed in the hippocampus of the normal rats.

Stathmin is a downstream protein of KIAA1199-PP2A

WebNov 27, 2024 · (f) Western blot analysis of phospho(p)-stathmin 1 S16, stathmin 1, and α-tubulin in total cell extracts from NB4 and NB4-R2 cells exposed to a vehicle or 1 μM … WebRabbit IgG was used as a negative control. b Western blotting analysis of KIAA1199, stathmin and phosphorylated stathmin (p-Stathmin, Ser16) in HCT116 cell transfected with indicated constructs. c ... gold coast train timetable https://reesesrestoration.com

Stathmin - Wikipedia

Web您好！欢迎来到炼石商城 请登录 注册 我的订单; 我的炼石 WebJun 19, 2024 · Immunoprecipitation analysis revealed the association of green fluorescent protein (GFP)-stathmin with Flag-p62 (Supplementary Data Fig. S3d ), the receptor for cargoes destined for degradation... Stathmin is a ubiquitous phosphorylated protein which makes it act as an intracellular relay for diverse regulatory pathways, functioning through a variety of second messengers. Its phosphorylation and gene expression are regulated throughout development [11] and in response to extracellular … See more Stathmin, also known as metablastin and oncoprotein 18 is a protein that in humans is encoded by the STMN1 gene. Stathmin is a highly conserved 17 kDa protein that is crucial for the regulation of the cell See more Stathmin, and the related proteins SCG10 and XB3, contain a N-terminal domain (XB3 contains an additional N-terminal hydrophobic region), … See more Stathmin interacts with two molecules of dimeric α,β-tubulin to form a tight ternary complex called the T2S complex. One mole of stathmin binds to two moles of tubulin dimers through the stathmin-like domain (SLD). When stathmin sequesters tubulin into the T2S … See more Mice without stathmin have deficiency in innate and learned fear. Stathmin−/− females do not assess threats well, leading to lack of … See more The function of Stathmin is to regulate the cytoskeleton of the cell. The cytoskeleton is made up of long hollow cylinders named microtubules. These microtubules are made up of alpha and beta tubulin heterodimers. The changes in cytoskeleton are … See more Stathmin's role in regulation of the cell cycle causes it to be an oncoprotein named oncoprotein 18 (op18). Stathmin (aka op18) can cause uncontrolled cell proliferation when mutated and not functioning properly. If stathmin is unable to bind to tubulin, it … See more • Sobel A (August 1991). "Stathmin: a relay phosphoprotein for multiple signal transduction?". Trends in Biochemical Sciences. 16 (8): … See more hchra webmail

Stathmin expression associates with vascular and immune

Category:Preclinical assessment of synergistic efficacy of MELK and CDK ...

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P-stathmin

Preclinical assessment of synergistic efficacy of MELK and CDK ...

Web靶向于her2的sirna表达载体在人乳腺癌细胞skbr3中的表达. 内容摘要：作者：鲍炜 张立红 付海京 贾林涛 张勇 刘家云 任新玲 温伟红 孟艳玲 王成济 杨安钢 作者：鲍炜 张立红 付海京 贾林涛 张勇 刘家云 任新玲 温伟红 孟艳玲 王成济 杨安钢 目的：探讨针对her2分子的rna干涉对 http://www.lianshimall.com/goods-5992238.html

P-stathmin

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WebStathmin 1 [p Ser25] Antibody Summary. Synthetic phosphopeptide derived from human Op18 around the phosphorylation site of Serine 25. p-Op18 (S25) pAb detects … WebMolecular Function. Definition. Stathmin is a ubiquitous, cytosolic 19-kDa protein, that is phosphorylated on up to four sites in response to many regulatory signals within cells. Its …

WebSep 9, 2024 · Expression of PRL-3 and stathmin in clinical samples and cell lines detected by western blot. (A–C) Expression of PRL-3 and stathmin in de novo myeloid leukemia patients. (D, E) Expression of PRL-3 and stathmin in myeloid leukemia cell lines. (*P<0.05, **P<0.01, vs. healthy normal control). Note: N, healthy normal control. P, de novo patient. WebStathmin 1 (STMN1), also known as leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18 (op18), phosphoprotein p19, prosolin, protein Pr22, and pp17, is a member of the stathmin family that encodes a ubiquitous cytosolic phosphoprotein that functions as an intracellular relay for regulatory signals of the cellular environment ...

WebSep 23, 2024 · A reduction in p-stathmin from the combination treatment destabilized microtubule assembly by tubulin depolymerization. The drug combination treatment in mice with human ACC xenografts resulted in a significantly lower tumor burden than those treated with single-agents and vehicle control groups. Conclusions WebApr 12, 2024 · STATHMIN-2 has been shown to be highly expressed in human motor neurons, the cells that primarily degenerate in ALS. ANQUR, a multi-center, randomized, double-blind, placebo-controlled multiple ascending dose study, is the first to assess a therapy that rescues STMN2 expression in patients with ALS.

WebMar 26, 2024 · We report a novel non-coding CA repeat in Stathmin-2 which is associated with sALS disease risk and has disease modifying effects. The potential value of this …

WebOp18/stathmin is a 17-kDa protein that has been recently revealed to bind tubulin and destabilize microtubules ( 19 ) and is negatively regulated by phosphorylation by a variety … gold coast train timetable brisbaneWebThe protein and mRNA expression of β-tubulin and MAP-1B was consistent with that of p-stathmin; it reached a peak on the 7th day, and then decreased in the rat hippocampus, … gold coast train stationsWebStathmin 1 is a microtubule-regulating protein that has an important role in the assembly and disassembly of the mitotic spindle . At the molecular level, Stathmin 1 depolymerizes microtubules by either sequestering free tubulin dimers or directly inducing microtubule-catastrophe . As mentioned before, Stathmin 1 is encoded by the human STMN1 ... hchra teaching strategies goldWebMay 1, 2009 · We have recently reported that stathmin, a microtubule regulatory protein, was expressed by human endometrial stroma, glandular, and vascular endothelium ( 12 ). Stathmin is a cytosolic phosphoprotein that contains four serine phosphorylation sites (Ser-16, -25, -38, and -63) at its N terminus ( 13 ). gold coast trains ventura caWebSep 28, 2024 · Supplementary Figure 1. Whole gel images of western blotting analysis. Western blot analysis for phopho (p)-Stathmin 1 S16, acetyl-α-tubulin K40 and caspase 3 (total and cleaved) in total cell extracts from Jurkat and Namalwa cells treated with the indicated concentrations of paclitaxel or for p-Stathmin 1 S16 and Stathmin 1 in total cell … gold coast train stopsWebFeb 22, 2010 · Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy† Human Molecular Genetics Oxford Academic Abstract. Spinal muscular atrophy (SMA), a motor neuron degeneration disorder, is caused by either mutations or deletions of survival motor neuron 1 (SMN1) gene gold coast train stations mapWebNov 15, 1998 · Stathmin is a small regulatory phosphoprotein integrating diverse intracellular signaling pathways. It is also the generic element of a protein family including the neural proteins SCG10, SCLIP, RB3 and its two splice variants RB3′ and RB3″. Stathmin itself was shown to interact in vitro with tubulin in a phosphorylation-dependent manner, … hch real estate monticello iowa