WebSep 29, 2024 · Furthermore, we confirmed that low expression of CTCF in CD4+ T cells from aGVHD cases is an important factor affecting histone H3K9/K14 hypoacetylation in the p53 promoter and p53 downregulation. Restoring CTCF expression in CD4+ T cells from aGVHD patients increased p53 amounts and corrected the imbalance of Th17 cells/Tregs. WebMar 19, 2024 · CTCF is required in a dose-dependent manner and is involved in cell cycle progression of alphabeta T cells in the thymus. These findings offer insight into general epigenetic mechanisms by which CTCF governs gene expression by orchestrating chromatin loop structures and by serving as a DNA-binding protein scaffold to recruit and …
Tcf1–CTCF cooperativity shapes genomic architecture to promote …
WebThe Myc-associated zinc finger protein (MAZ) was identified and characterized as a regulatory protein associated with MYC gene expression (), and independently as a regulatory factor called Pur-1 that can activate an insulin promoter in HeLa cells ().It was also identified as a serum amyloid A-activating factor and named SAF-1 ().Previous … WebOct 16, 2008 · In Ctcf knockout animals, however, these cells are small and blocked in the cell cycle due to increased expression of the cyclin-CDK inhibitors p21 and p27. Taken together, our results show that CTCF is required in a dose-dependent manner and is involved in cell cycle progression of αβ T cells in the thymus. cult coffee roaster and tea
Elevated enhancer-oncogene contacts and higher oncogene
WebSmits et al. report that TLX3 chromosomal translocations in T cell acute lymphoblastic leukemia patients recurrently include intervening CTCF-binding sites in the breakpoint area. Pressure to acquire inactivating aberrations in CTCF abrogate consequential enhancer insulation that promotes TLX3 promoter to BCL11B enhancer looping boosts higher … WebMar 21, 2024 · CTCF (CCCTC-Binding Factor) is a Protein Coding gene. Diseases associated with CTCF include Intellectual Developmental Disorder, Autosomal Dominant … WebHere we show that the depletion of SATB1 in human and murine T cells leads to transcriptional dysregulation for genes involved in T cell activation, as well as alterations … east herts council waste and recycling