Circrna protein interaction
WebMar 23, 2024 · CircRNA-protein interactions regulating muscle development and diseases. (A) PURA and PURB inhibit the transcription of MHC, and circsamd4 promotes … WebCircularRNA (circRNA) is an emerging ncRNA with a highly stable closed-loop structure formed by reverse splicing at the 3′ and 5′ ends, which is formed mainly by exons, introns or intergenic regions [ 9, 10, 11 ]. MicroRNA (miRNA) is a class of endogenous non-coding RNA, around 21–25 nucleotides in length [ 12 ].
Circrna protein interaction
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WebDec 14, 2024 · CircRNAs exert biological functions by acting as transcriptional regulators, microRNA (miR) sponges and protein templates. Moreover, emerging evidence has … WebA comprehensive analysis of differentially expressed (DE)circRNA, DEmiRNA and DEmRNA functions was performed by Gene Ontology Biological Processes (GO-BP), …
WebCircular RNAs (circRNAs), with their crucial roles in gene regulation and disease development, have become rising stars in the RNA world. To understand the regulatory function of circRNAs, many studies focus on the interactions between circRNAs and RNA-binding proteins (RBPs). WebJan 7, 2024 · The significant function of circRNAs in cancer was recognized in recent work, so a well-organized resource is required for characterizing the interactions between …
WebSince circRNA-protein interactions are more likely based on the tertiary structures of circRNA, the binding RNA fragments may be at multiple sites, and of varying nucleotides in length. In addition, the junctional region of …
WebCircRNA as a Protein Sponge. In addition to being a miRNA sponge, circRNA can be a sponge for some proteins, ... through gene sequencing of pancreatic cancer tissue and paired para-carcinoma tissue to establish the hypothesis of the circRNA–miRNA–mRNA interaction network in this disease. The functions of these three types of RNAs were ...
WebThe interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function. The widespread expression of circular RNAs (circRNAs) is … st peter rickerscote facebookWebSep 26, 2024 · CircRNAs can function as miRNA sponges, thereby reducing their ability to target mRNAs. We hypothesize that circRNAs may bind, store, sort, and sequester … st peters 6th form gloucesterWebApr 12, 2024 · Recently, it has been reported that circRNA-protein interactions may play a role in the progression of various cancers . Thus, we performed RNA pull-down and mass spectrometry (MS) analysis to ... st peter rock missionary baptist churchWebApr 13, 2024 · The analysis of RT-qPCR and Western blot demonstrated that the mRNA and protein expression levels of genes involved in differentiation rose. These data revealed … rotherham golf club weddingsWebAug 4, 2024 · CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene … st peter regional treatment center minnesotaWebCircRNAs may also interact with regulatory RBPs, including through their activity as protein sponges, decoys, scaffolds, and recruiters, and further affect the fate of their target … rotherham gpWebJan 15, 2024 · The circRNA-ACAP2 interaction regulated the expression of miR-21-5p, and miR-21-5p regulated the expression of Tiam1. ... *P< 0.01. (G) Relative protein expression of Tiam1 when circRNA-ACAP2 expression was knocked down. Each bar represents the mean of three independent experiments. *P< 0.05. (H) Relative protein … rotherham gp practices